Medizinscher Fortschritt erfordert eine enge Verzahnung von Wissenschaft und ärztlicher Kunst. Lungenerkrankungen nehmen weltweit zu. Die betroffenen Menschen leiden unter starker Luftnot und die Erkrankungen verkürzen die verbleibende Lebenszeit. Neue therapeutische Ansätze sind dringend notwendig. An vielen deutschen Universitäten ist die Pneumologie jedoch nicht vertreten, dies steht dem wissenschaftlichem Fortschritt und damit der Entwicklung neuer Therapieansätze entgegen. Um den Patienten gerecht zu werden stellen die KEM sich dieser Aufgabe und haben eine wissenschaftliche Abteilung für Pneumologie gegründet. Es werden laufend Studien im Bereich der Schlaf- und Beatmungsmedizin durchgeführt. Zum Teil erfolgen diese Untersuchungen gemeinsam mit weltweiten Partner und international tätigen Unternehmen, da nur so Fortschritte zum Wohl der Patienten erzielt werden können.
Hohe ethische Standards stellen die Basis jeder Wissenschaft dar. Die von uns durchgeführten Studien werden durch die Ethik-Kommission der Universität Witten Herdecke streng geprüft.
Wissenschaftliche Mitarbeiter
Ulrike Domanski (Leitung)
Tel.: +49 201 174-22058
E-Mail: u.domanski@kem-med.com
Maik Schröder
Tel.: +49 201 174-22057
E-Mail: m.schroeder@kem-med.com
Studiennummer: ClinicalTrials.gov Identifier: NCT05287555
Studientitel: Efficacy of Telemetry-assisted Care in Home Vented COPD (TeleInterVENT)
[Randomisiert-kontrollierte klinische Studie an häuslich beatmeten COPD-Patienten zur Überprüfung der Wirksamkeit einer telemetrisch unterstützten Fernbetreuung durch das Beatmungszentrum im Vergleich zur stationären, halbjährlichen Beatmungskontrolle gemäß Leitlinie]
Studieninhalt: In dieser Studie an Patienten mit chronisch obstruktiver Lungenerkrankung (COPD) soll untersucht werden, ob die telemedizinische Überwachung ihres nicht invasiven Beatmungsgeräts (NIV) in Verbindung mit einer gezielten, bedarfsgerechten Intervention bei zunehmenden Symptomen oder Auffälligkeiten in der Beatmung die Therapietreue und die Effizienz verbessern und die Notwendigkeit von Krankenhausaufenthalten verringern kann.
Verantwortlicher Arzt: Prof Dr Georg Nilius
Status: geöffnet
Studiennummer: ClinicalTrials.gov Identifier: NCT03783884; Eudamed-Nr.: CIV-19-09-029824
Studientitel: A Protocol Comparing Temporary Transvenous Diaphragm Pacing to Standard of Care for Weaning from Mechanical Ventilation in ICU Patients (RESCUE 3)
[Prüfplan zum Vergleich der temporären transvenösen Zwerchfellstimulation mit der Standardbehandlung für die Beatmungsentwöhnung bei ITS-Patienten (RESCUE 3)]
Studieninhalt: Randomisierte, kontrollierte, unverblindete, multizentrische, adaptive klinische Studie zur Untersuchung der sicheren und wirksamen Leistung des Lungpacer-Therapiesystems zur Zwerchfellstimulation bei Patienten, bei denen eine Beatmungsentwöhnung fehlgeschlagen ist.
Verantwortlicher Arzt: Prof Dr Georg Nilius
Status: geöffnet
Studiennummer: ClinicalTrials.gov Identifier: NCT04090671
Studientitel: Evaluation of the Multidimensional Dyspnea Profile (MDP)
[Das Multidimensionale Dyspnoe Profil (MDP) bei COPD, Herzinsuffizienz, COVID-19 und OSA. Eine Multi-Center-Studie.]
Studieninhalt: Aim of this multicenter prospective cohort study is the evaluation of the multidimensional qualities of dyspnea in COPD, CHF, OSA, and COVID-19 using the Multidimensional Dyspnea Profile (MDP).
Verantwortlicher Arzt: Prof Dr Georg Nilius
Status: geöffnet
Studiennummer: ClinicalTrials.gov Identifier: NCT04703023
Studientitel: Comparison of water sorption capacity and the composition of bronchial fluids of healthy persons and patients with chronic obstructive pulmonary disease (COPD)
Studieninhalt: This pilot study is basic research on the properties of bronchial mucus. Aim of the study is to examine the sorption and desorption properties, the mucin concentration, and the structure of the mucus from healthy airways and patients with Chronic Obstructive Pulmonary Disease (COPD). Findings will provide insights into possible treatment programs targeted at altering specific mucus components.
Verantwortlicher Arzt: Prof Dr Georg Nilius
Status: geöffnet
Studiennummer: ClinicalTrials.gov Identifier: NCT02698059
Studientitel: A Multi-center, Two-stage, Single-arm, Prospective, First-night Order Cross-over, Evaluator-blind Study to Evaluate the Efficacy, Safety and Tolerance of the iNAP® Sleep Therapy System in Adults With Obstructive Sleep Apnea (OSA)
Studieninhalt: This is a post-marketing surveillance study to investigate the efficacy and safety of the Negative Pressure Sleep Therapy System for the treatment of obstructive sleep apnea.
Verantwortlicher Arzt: Prof Dr Georg Nilius
Status: Rekrutierung beendet
Studiennummer: ClinicalTrials.gov Identifier: NCT04407949
Studientitel: Comparison of Sleep Disordered Breathing Events Detected by the CPAP Device „prismaLine“ with Polysomnography
Studieninhalt: Evaluation of residual sleep disordered breathing (SDB) under continuous positive airway pressure (CPAP) therapy with comparison of the automatic detected SDB event indices from CPAP machines with manual scored polysomnography (PSG).
Verantwortlicher Arzt: Prof Dr Georg Nilius
Status: Rekrutierung beendet
ICS haben wohl einen Platz in der ambulanten Covid-Versorgung.
Nilius G.MMW Fortschr Med. 2022 Jan;164(1):24-26. doi: 10.1007/s15006-021-0542-z.PMID: 35043319 Rezension. Deutsch. Keine Zusammenfassung verfügbar.
Vorteil inhalativer topischer Steroide bei Risikopatienten bestätigt.
Nilius G.Pneumo-Neuigkeiten. 2021;13(6):10-11. doi: 10.1007/s15033-021-2776-y. Epub 2021, 13. Dezember.PMID: 34925624 Rezension. Deutsch. Keine Zusammenfassung verfügbar.
Inhalative Steroide senken die ACE-2-Genexpression auf dem Bronchialepithel.
Nilius G.Pneumo-Neuigkeiten. 2021;13(3):12-13. doi: 10.1007/s15033-021-2715-y. Epub 2021, 25. Juni.PMID: 34149942 Rezension. Deutsch. Keine Zusammenfassung verfügbar.
Konsequente CPAP-Beatmung verbessert das Gedächtnis.
Nilius G.MMW Fortschr Med. 2021 Nov;163(19):26-27. doi: 10.1007/s15006-021-0367-9.PMID: 34708361 Rezension. Deutsch. Keine Zusammenfassung verfügbar.
Rekonvaleszenten-Plasma mildert COVID-19-Verlauf bei Älteren.
Nilius G.Pneumo Nachrichten. 2021; 13 (2): 14-16. doi: 10.1007 / s15033-021-2684-1. Epub 2021 17. Mai.PMID: 33968265 Deutsche. Keine Zusammenfassung verfügbar.
Franke KJ, Domanski U, Schröder M, Nilius G.
Sleep Breath. 2020 Aug 26. doi: 10.1007/s11325-020-02176-0. Online ahead of print.
PMID: 32845475
Bischof F, Egresits J, Schulz R, Randerath WJ, Galetke W, Budweiser S, Nilius G, Arzt M, Hetzenecker A; GERSAN Investigators.
Sleep Breath. 2020 Sep;24(3):941-951. doi: 10.1007/s11325-019-01926-z. Epub 2019 Aug 28.
PMID: 31463779
Nilius G, Schroeder M, Domanski U, Tietze A, Schäfer T, Franke KJ.
Respiration. 2019 Aug 7:1-11. doi: 10.1159/000501656. [Epub ahead of print]
PMID: 31390641
[German Translation and Linguistic Validation of the Multidimensional Dyspnea Profile (MDP)].
Stump A, Schröder M, Domanski U, Franke KJ, Nilius G.
Pneumologie. 2019 Aug;73(8):470-473. doi: 10.1055/a-0861-1516. Epub 2019 Jun 17. German.
PMID: 31207660
[Digital Health in Respiratory Medicine – Current Status].
Dreher M, Jany B, Nilius G, Woehrle H, Koczulla R.
Dtsch Med Wochenschr. 2019 Apr;144(7):457-462. doi: 10.1055/a-0740-8692. Epub 2019 Mar 29. German.
PMID: 30925600
1: Schulz R, Bischof F, Galetke W, Gall H, Heitmann J, Hetzenecker A, Laudenburg
M, Magnus TJ, Nilius G, Priegnitz C, Randerath W, Schröder M, Treml M, Arzt M;
German Sleep Apnea Research Network (GERSAN). CPAP therapy improves erectile
function in patients with severe obstructive sleep apnea. Sleep Med. 2018 Apr 10.
pii: S1389-9457(18)30096-0. doi: 10.1016/j.sleep.2018.03.018. [Epub ahead of
print] PubMed PMID: 29773460.
2: Nilius G, Domanski U, Schroeder M, Woehrle H, Graml A, Franke KJ. Mask
humidity during CPAP: influence of ambient temperature, heated humidification and
heated tubing. Nat Sci Sleep. 2018 May 1;10:135-142. doi: 10.2147/NSS.S158856.
eCollection 2018. PubMed PMID: 29750062; PubMed Central PMCID: PMC5935083.
3: Kessler R, Casan-Clara P, Koehler D, Tognella S, Viejo JL, Dal Negro RW,
Díaz-Lobato S, Reissig K, Rodríguez González-Moro JM, Devouassoux G, Chavaillon
JM, Botrus P, Arnal JM, Ancochea J, Bergeron-Lafaurie A, De Abajo C, Randerath
WJ, Bastian A, Cornelissen CG, Nilius G, Texereau JB, Bourbeau J. COMET: a
multicomponent home-based disease-management programme versus routine care in
severe COPD. Eur Respir J. 2018 Jan 11;51(1). pii: 1701612. doi:
10.1183/13993003.01612-2017. Print 2018 Jan. PubMed PMID: 29326333.
4: Nilius G, Domanski U, Schroeder M, Franke KJ, Hogrebe A, Margarit L, Stoica M,
d’Ortho MP. A randomized controlled trial to validate the Alice PDX ambulatory
device. Nat Sci Sleep. 2017 Jun 6;9:171-180. doi: 10.2147/NSS.S133789.
eCollection 2017. PubMed PMID: 28652835; PubMed Central PMCID: PMC5476768.
5: Nilius G, Katamadze N, Domanski U, Schroeder M, Franke KJ. Non-invasive
ventilation with intelligent volume-assured pressure support versus
pressure-controlled ventilation: effects on the respiratory event rate and sleep
quality in COPD with chronic hypercapnia. Int J Chron Obstruct Pulmon Dis. 2017
Mar 30;12:1039-1045. doi: 10.2147/COPD.S126970. eCollection 2017. PubMed PMID:
28408814; PubMed Central PMCID: PMC5383083.
6: Randerath W, Bögel M, Franke C, Hellmann A, Jany B, Nilius G, Penzel T,
Voshaar T, Wiater A. [Positionpaper on Telemonitoring in Sleep-Related Breathing
Disorders]. Pneumologie. 2017 Feb;71(2):81-85. doi: 10.1055/s-0042-124083. Epub
2017 Feb 21. German. PubMed PMID: 28222476.
7: Franke KJ, Domanski U, Schroeder M, Jansen V, Artmann F, Weber U, Ettler R,
Nilius G. Telemonitoring of home exercise cycle training in patients with COPD.
Int J Chron Obstruct Pulmon Dis. 2016 Nov 11;11:2821-2829. eCollection 2016.
PubMed PMID: 27956829; PubMed Central PMCID: PMC5113934.
8: Möller W, Feng S, Domanski U, Franke KJ, Celik G, Bartenstein P, Becker S,
Meyer G, Schmid O, Eickelberg O, Tatkov S, Nilius G. Nasal high flow reduces dead
space. J Appl Physiol (1985). 2017 Jan 1;122(1):191-197. doi:
10.1152/japplphysiol.00584.2016. Epub 2016 Nov 17. PubMed PMID: 27856714; PubMed
Central PMCID: PMC5283847.
9: Fricke K, Tatkov S, Domanski U, Franke KJ, Nilius G, Schneider H. Nasal high
flow reduces hypercapnia by clearance of anatomical dead space in a COPD patient.
Respir Med Case Rep. 2016 Aug 26;19:115-7. doi: 10.1016/j.rmcr.2016.08.010.
eCollection 2016. PubMed PMID: 27668173; PubMed Central PMCID: PMC5024502.
10: Franke KJ, Linzenbold W, Nuessle D, Enderle M, Boesmueller H, Nilius G,
Hetzel J. A New Tool for Transbronchial Cryobiopsies in the Lung: An Experimental
Feasibility ex vivo Study. Respiration. 2016; 91(3):228-34. doi:
10.1159/000443990. Epub 2016 Feb 23. PubMed PMID: 26901791.
11: Bräunlich J, Nilius G. [Nasal Highflow (NHF): A New Therapeutic Option for
the Treatment of Respiratory Failure]. Pneumologie. 2016 Jan;70(1):49-54. doi:
10.1055/s-0041-110286. Epub 2016 Jan 20. Review. German. PubMed PMID: 26789432.
12: Nilius G. Response to „Effect of APAP and heated humidification with a heated
breathing tube on adherence, quality of life, and nasopharyngeal complaints“.
Sleep Breath. 2016 Mar;20(1):253. doi: 10.1007/s11325-015-1273-0. Epub 2015 Oct
- PubMed PMID: 26476548.
13: Franke KJ, Hein M, Domanski U, Nilius G, Schroeder M, Wohlschlaeger J,
Theegarten D. Transbronchial Catheter Aspiration and Transbronchial Needle
Aspiration in the Diagnostic Workup of Peripheral Lung Lesions. Lung. 2015
Oct;193(5):767-72. doi: 10.1007/s00408-015-9763-1. Epub 2015 Jul 9. PubMed PMID:
26156311.
14: Nilius G, Franke KJ, Domanski U, Schroeder M, Ruhle KH. Effect of APAP and
heated humidification with a heated breathing tube on adherence, quality of life,
and nasopharyngeal complaints. Sleep Breath. 2016 Mar;20(1):43-9. doi:
10.1007/s11325-015-1182-2. Epub 2015 May 10. PubMed PMID: 25957615.
15: Kamps N, Galetke W, Hein H, Nilius G, Rühle KH, Voshaar T, Wiater A,
Randerath W. [When patients bring their own medical devices into hospital –
position paper of the German Society for Sleep Research and Sleep Medicine,
Section 8 of the German Society of Pneumology and the Association of
Pneumological hospitals]. Dtsch Med Wochenschr. 2015 Feb; 140(4):281-4. doi:
10.1055/s-0041-100479. Epub 2015 Feb 19. German. PubMed PMID: 25704526.
16: Rohde GG, Koch A, Welte T; ABACOPD study group. Randomized double blind
placebo-controlled study to demonstrate that antibiotics are not needed in
moderate acute exacerbations of COPD–the ABACOPD study. BMC Pulm Med. 2015 Jan
27;15:5. doi: 10.1186/1471-2466-15-5. PubMed PMID: 25623589; PubMed Central
PMCID: PMC4350292.
17: Esquinas AM, Nilius G. Transnasal insufflation or continuous positive airway
pressure (CPAP) in acute stroke. The next step or a new dilemma? Sleep Breath.
2015 Mar;19(1):1-2. doi: 10.1007/s11325-014-1061-2. Epub 2014 Oct 7. PubMed PMID:
25287008.
18: Randerath WJ, Hein H, Arzt M, Galetke W, Nilius G, Penzel T, Rasche K, Rühle
KH, Mayer G. [Consensus paper on the diagnosis and treatment of sleep disordered
breathing]. Pneumologie. 2014 Feb;68(2):106-23. doi: 10.1055/s-0033-1359221. Epub
2014 Feb 4. German. PubMed PMID: 24497048.
19: Franke KJ, Nilius G, Domanski U, Rühle KH. [Unilateral reduction of lung
volume by application of intrabronchial valves on patients selected after
endoscopic collateral ventilation assessment]. Pneumologie. 2014 Feb;68(2):100-5.
doi: 10.1055/s-0033-1359025. Epub 2013 Dec 16. German. PubMed PMID: 24343242.
20: Rühle KH, Franke KJ, Domanski U, Schröder M, Nilius G. [New developments in
X-PAP therapy for obstructive and central sleep-disordered breathing].
Pneumologie. 2013 Oct;67(10):551-9; quiz 560-1. doi: 10.1055/s-0033-1344494. Epub
2013 Oct 10. German. PubMed PMID: 24113886.
21: Franke KJ, Nilius G, Ruehle KH, Enderle MD, Linzenbold W, von Weyhern CH. The
cryo-needle: a new tool for histological biopsies. A feasibility study. Lung.
2013 Dec;191(6):611-7. doi: 10.1007/s00408-013-9502-4. Epub 2013 Aug 30. PubMed
PMID: 23990134.
22: Rühle KH, Franke KJ, Domanski U, Schröder M, Nilius G. [Telemonitoring of
bike exercise training in patients with obstructive sleep apnoea]. Pneumologie.
2013 Jun;67(6):321-6. doi: 10.1055/s-0033-1344151. Epub 2013 May 22. German.
PubMed PMID: 23700134.
23: Rühle KH, Karweina D, Domanski U, Nilius G. [Technique and clinical
importance of breathing wave generators]. Pneumologie. 2012 Oct;66(10):579-83.
doi: 10.1055/s-0032-1325665. Epub 2012 Sep 17. Review. German. PubMed PMID:
22987327.
24: Nilius G, Franke KJ, Domanski U, Rühle KH, Kirkness JP, Schneider H. Effects
of nasal insufflation on arterial gas exchange and breathing pattern in patients
with chronic obstructive pulmonary disease and hypercapnic respiratory failure.
Adv Exp Med Biol. 2013;755:27-34. PubMed PMID: 22826046.
25: Bauer TT, Nilius G, Grüning W, Rasche K. [Diagnosis and therapy of COPD
exacerbation]. Med Klin Intensivmed Notfmed. 2012 Apr;107(3):172-8. doi:
10.1007/s00063-011-0065-y. Epub 2012 Apr 4. Review. German. PubMed PMID:
22476704.
26: Ruhle KH, Domanski U, Nilius G. Obstructive pressure peak: a new method for
differentiation of obstructive and central apneas under auto-CPAP therapy. Sleep
Breath. 2013 Mar;17(1):111-5. PubMed PMID: 22302201.
27: Rühle KH, Kuhtin O, Domanski U, Franke KJ, Nilius G. [Detection of daytime
sleepiness using Epworth Sleepiness Scale and a 3-item questionnaire in
obstructive sleep apnea]. Pneumologie. 2012 Mar;66(3):184-7. doi:
10.1055/s-0031-1291634. Epub 2012 Jan 27. German. PubMed PMID: 22287055.
28: Franke KJ, Bruckner C, Szyrach M, Ruhle KH, Nilius G, Theegarten D. The
contribution of endobronchial ultrasound-guided forceps biopsy in the diagnostic
workup of unexplained mediastinal and hilar lymphadenopathy. Lung. 2012
Apr;190(2):227-32. doi: 10.1007/s00408-011-9341-0. Epub 2011 Oct 22. PubMed PMID:
22037795.
29: Franke KJ, Bruckner C, Nilius G, Ruhle KH. Investigation of the flexibility
of bronchoscopes. Eur J Med Res. 2011 Sep 12;16(9):420-4. PubMed PMID: 22024444;
PubMed Central PMCID: PMC3352149.
30: Rühle KH, Domanski U, Franke KJ, Bloch M, Nilius G. [Telemedicine and
training in COPD]. Pneumologie. 2011 Oct;65(10):596-601. doi:
10.1055/s-0030-1256738. Epub 2011 Oct 20. Review. German. PubMed PMID: 22015486.
31: Rühle KH, Karweina D, Domanski U, Nilius G. [Clinical views on biosignal
processing of ventilation in sleep medicine]. Pneumologie. 2011 Feb;65(2):89-93.
doi: 10.1055/s-0030-1255819. Epub 2010 Oct 18. Review. German. PubMed PMID:
20957599.
32: Ruhle KH, Franke KJ, Domanski U, Nilius G. Quality of life, compliance, sleep
and nasopharyngeal side effects during CPAP therapy with and without controlled
heated humidification. Sleep Breath. 2011 Sep;15(3):479-85. doi:
10.1007/s11325-010-0363-2. Epub 2010 May 26. PubMed PMID: 20503074.
33: Franke KJ, Nilius G, Morgenstern S, Ruhle KH. Removal of the tracheal tube
after prolonged mechanical ventilation: assessment of risk by oscillatory
impedance. Respiration. 2011;81(2):118-23. doi: 10.1159/000314073. Epub 2010 Apr
- PubMed PMID: 20424425.
34: Franke KJ, Nilius G, Rühle KH. [Use of cryoextraction in different types of
airway obstruction]. Pneumologie. 2010 Jun;64(6):387-9. doi:
10.1055/s-0029-1244046. Epub 2010 Apr 13. German. PubMed PMID: 20391320.
35: Rühle KH, Domanski U, Schröder M, Franke KJ, Nilius G. [Heated humidification
during CPAP with and without tube insulation]. Pneumologie. 2010 May;64(5):316-9.
doi: 10.1055/s-0029-1244073. Epub 2010 Apr 12. German. PubMed PMID: 20387197.
36: Franke KJ, Theegarten D, Hann von Weyhern C, Nilius G, Brueckner C, Hetzel J,
Hetzel M, Ruhle KH, Enderle MD, Szyrach MN. Prospective controlled animal study
on biopsy sampling with new flexible cryoprobes versus forceps: evaluation of
biopsy size, histological quality and bleeding risk. Respiration.
2010;80(2):127-32. doi: 10.1159/000287251. Epub 2010 Feb 17. PubMed PMID:
20160432.
37: Nilius G, Wessendorf T, Maurer J, Stoohs R, Patil SP, Schubert N, Schneider
- Predictors for treating obstructive sleep apnea with an open nasal cannula
system (transnasal insufflation). Chest. 2010 Mar;137(3):521-8. doi:
10.1378/chest.09-0357. Epub 2009 Dec 1. PubMed PMID: 19952061.
38: Nilius G, Burian S, Franke KJ, Van’t Hoog T, Domanski U, Rühle KH. [Effects
of a breath-triggered modulation of positive airway pressure ventilation on the
AHI from patients with obstructive sleep apnoea]. Pneumologie. 2009
Aug;63(8):433-8. doi: 10.1055/s-0029-1214817. Epub 2009 Aug 7. German. PubMed
PMID: 19670102.
39: Rühle KH, Karweina D, Domanski U, Nilius G. [Characteristics of auto-CPAP
devices during the simulation of sleep-related breathing flow patterns].
Pneumologie. 2009 Jul;63(7):390-8. doi: 10.1055/s-0029-1214746. Epub 2009 Jul 9.
German. PubMed PMID: 19591085.
40: Franke KJ, Szyrach M, Nilius G, Hetzel J, Hetzel M, Ruehle KH, Enderle MD.
Experimental study on biopsy sampling using new flexible cryoprobes: influence of
activation time, probe size, tissue consistency, and contact pressure of the
probe on the size of the biopsy specimen. Lung. 2009 Aug;187(4):253-9. doi:
10.1007/s00408-009-9156-4. Epub 2009 Jun 23. PubMed PMID: 19548030.
41: Rühle KH, Bloch M, Franke KJ, Nilius G. [Telemonitoring of arm ergometric
training in COPD patients. A pilot study]. Pneumologie. 2009 Jun;63(6):314-8.
doi: 10.1055/s-0028-1119701. Epub 2009 Mar 16. German. PubMed PMID: 19291617.
42: Franke KJ, Nilius G, Ruhle KH. Transbronchial catheter aspiration compared to
forceps biopsy in the diagnosis of peripheral lung cancer. Eur J Med Res. 2009
Jan 28;14(1):13-7. PubMed PMID: 19258205; PubMed Central PMCID: PMC3352199.
43: Sebastian M, Kiewe P, Schuette W, Brust D, Peschel C, Schneller F, Rühle KH,
Nilius G, Ewert R, Lodziewski S, Passlick B, Sienel W, Wiewrodt R, Jäger M,
Lindhofer H, Friccius-Quecke H, Schmittel A. Treatment of malignant pleural
effusion with the trifunctional antibody catumaxomab (Removab) (anti-EpCAM x
Anti-CD3): results of a phase 1/2 study. J Immunother. 2009
Feb-Mar;32(2):195-202. doi: 10.1097/CJI.0b013e318195b5bb. PubMed PMID: 19238019.
44: Rühle KH, Franke KJ, Morgenstern S, Nilius G. [Exercise testing by
spiroergometry in a patient with sarcoidosis stage II. An unusual combination of
functional impairments]. Pneumologie. 2009 Feb;63(2):80-5. doi:
10.1055/s-0028-1119434. Epub 2009 Feb 13. German. PubMed PMID: 19219768.
45: Rühle KH, Franke KJ, Nilius G. [Microsleep, sleepiness and driving
performance in patients with sleep apnoea syndrome]. Pneumologie. 2008
Oct;62(10):595-601. doi: 10.1055/s-2008-1038203. Epub 2008 Aug 18. Review.
German. PubMed PMID: 18711696.
46: Nilius G, Domanski U, Franke KJ, Ruhle KH. Impact of a controlled heated
breathing tube humidifier on sleep quality during CPAP therapy in a cool sleeping
environment. Eur Respir J. 2008 Apr;31(4):830-6. doi: 10.1183/09031936.00161806.
Epub 2008 Jan 9. PubMed PMID: 18184678.
47: Ruhle KH, Nilius G. Mouth breathing in obstructive sleep apnea prior to and
during nasal continuous positive airway pressure. Respiration. 2008;76(1):40-5.
Epub 2007 Nov 28. PubMed PMID: 18042974.
48: Rühle KH, Domanski U, Franke KJ, Nilius G. [Studies of leakage measurements
of automatic CPAP-devices]. Pneumologie. 2007 Apr;61(4):213-8. German. PubMed
PMID: 17455133.
49: Rühle KH, Domanski U, Happel A, Nilius G. [Analysis of expiratory pressure
reduction (C-Flex method) during CPAP therapy]. Pneumologie. 2007 Feb;61(2):86-9.
German. PubMed PMID: 17290312.
50: Nilius G, Franke KJ, Domanski U, Rühle KH. [Upper airway complaints of
patients with obstructive sleep apnea – effect of CPAP]. Pneumologie. 2007
Jan;61(1):15-9. German. PubMed PMID: 17253207.
51: Franke KJ, Nilius G, Rühle KH. [Frequency of cytological procedures in
diagnostic bronchoscopy of peripheral pulmonary modules and masses]. Pneumologie.
2006 Nov;60(11):663-6. German. PubMed PMID: 17109263.
52: Nilius G, Happel A, Domanski U, Ruhle KH. Pressure-relief continuous positive
airway pressure vs constant continuous positive airway pressure: a comparison of
efficacy and compliance. Chest. 2006 Oct;130(4):1018-24. PubMed PMID: 17035433.
53: Franke KJ, Nilius G, Rühle KH. [Transbronchial biopsy in comparison with
catheter aspiration in the diagnosis of peripheral pulmonary nodules].
Pneumologie. 2006 Jan;60(1):7-10. German. PubMed PMID: 16429388.
54: Franke KJ, Nilius G, Rühle KH. [Cryorecanalization of an endobronchial
lipoma]. Pneumologie. 2005 Oct;59(10):685-8. German. PubMed PMID: 16222580
