Medizinscher Fortschritt erfordert eine enge Verzahnung von Wissenschaft und ärztlicher Kunst. Lungenerkrankungen nehmen weltweit zu. Die betroffenen Menschen leiden unter starker Luftnot und die Erkrankungen verkürzen die verbleibende Lebenszeit. Neue therapeutische Ansätze sind dringend notwendig. An vielen deutschen Universitäten ist die Pneumologie jedoch nicht vertreten, dies steht dem wissenschaftlichem Fortschritt und damit der Entwicklung neuer Therapieansätze entgegen. Um den Patienten gerecht zu werden stellen die KEM sich dieser Aufgabe und haben eine wissenschaftliche Abteilung für Pneumologie gegründet. Es werden laufend Studien im Bereich der Schlaf- und Beatmungsmedizin durchgeführt. Zum Teil erfolgen diese Untersuchungen gemeinsam mit weltweiten Partner und international tätigen Unternehmen, da nur so Fortschritte zum Wohl der Patienten erzielt werden können.

Hohe ethische Standards stellen die Basis jeder Wissenschaft dar. Die von uns durchgeführten Studien werden durch die Ethik-Kommission der Universität Witten Herdecke streng geprüft.

 

Wissenschaftliche Mitarbeiter

Ulrike Domanski (Leitung)
Tel.: +49 201 174-22058
E-Mail: u.domanski@kem-med.com

Maik Schröder
Tel.: +49 201 174-22057
E-Mail: m.schroeder@kem-med.com

 

Studiennummer: ClinicalTrials.gov Identifier: NCT05287555

Studientitel: Efficacy of Telemetry-assisted Care in Home Vented COPD (TeleInterVENT)

[Randomisiert-kontrollierte klinische Studie an häuslich beatmeten COPD-Patienten zur Überprüfung der Wirksamkeit einer telemetrisch unterstützten Fernbetreuung durch das Beatmungszentrum im Vergleich zur stationären, halbjährlichen Beatmungskontrolle gemäß Leitlinie]

Studieninhalt: In dieser Studie an Patienten mit chronisch obstruktiver Lungenerkrankung (COPD) soll untersucht werden, ob die telemedizinische Überwachung ihres nicht invasiven Beatmungsgeräts (NIV) in Verbindung mit einer gezielten, bedarfsgerechten Intervention bei zunehmenden Symptomen oder Auffälligkeiten in der Beatmung die Therapietreue und die Effizienz verbessern und die Notwendigkeit von Krankenhausaufenthalten verringern kann.

Verantwortlicher Arzt: Prof Dr Georg Nilius

Status: geöffnet

 

Studiennummer: ClinicalTrials.gov Identifier: NCT03783884; Eudamed-Nr.: CIV-19-09-029824

Studientitel: A Protocol Comparing Temporary Transvenous Diaphragm Pacing to Standard of Care for Weaning from Mechanical Ventilation in ICU Patients (RESCUE 3)

[Prüfplan zum Vergleich der temporären transvenösen Zwerchfellstimulation mit der Standardbehandlung für die Beatmungsentwöhnung bei ITS-Patienten (RESCUE 3)]

Studieninhalt: Randomisierte, kontrollierte, unverblindete, multizentrische, adaptive klinische Studie zur Untersuchung der sicheren und wirksamen Leistung des Lungpacer-Therapiesystems zur Zwerchfellstimulation bei Patienten, bei denen eine Beatmungsentwöhnung fehlgeschlagen ist.

Verantwortlicher Arzt: Prof Dr Georg Nilius

Status: geöffnet

 

Studiennummer: ClinicalTrials.gov Identifier: NCT04090671

Studientitel: Evaluation of the Multidimensional Dyspnea Profile (MDP)

[Das Multidimensionale Dyspnoe Profil (MDP) bei COPD, Herzinsuffizienz, COVID-19 und OSA. Eine Multi-Center-Studie.]

Studieninhalt: Aim of this multicenter prospective cohort study is the evaluation of the multidimensional qualities of dyspnea in COPD, CHF, OSA, and COVID-19 using the Multidimensional Dyspnea Profile (MDP).

Verantwortlicher Arzt: Prof Dr Georg Nilius

Status: geöffnet

 

Studiennummer: ClinicalTrials.gov Identifier: NCT04703023

Studientitel: Comparison of water sorption capacity and the composition of bronchial fluids of healthy persons and patients with chronic obstructive pulmonary disease (COPD)

Studieninhalt: This pilot study is basic research on the properties of bronchial mucus. Aim of the study is to examine the sorption and desorption properties, the mucin concentration, and the structure of the mucus from healthy airways and patients with Chronic Obstructive Pulmonary Disease (COPD). Findings will provide insights into possible treatment programs targeted at altering specific mucus components.

Verantwortlicher Arzt: Prof Dr Georg Nilius

Status: geöffnet

 

Studiennummer: ClinicalTrials.gov Identifier: NCT02698059

Studientitel: A Multi-center, Two-stage, Single-arm, Prospective, First-night Order Cross-over, Evaluator-blind Study to Evaluate the Efficacy, Safety and Tolerance of the iNAP® Sleep Therapy System in Adults With Obstructive Sleep Apnea (OSA)

Studieninhalt: This is a post-marketing surveillance study to investigate the efficacy and safety of the Negative Pressure Sleep Therapy System for the treatment of obstructive sleep apnea.

Verantwortlicher Arzt: Prof Dr Georg Nilius

Status: Rekrutierung beendet

 

Studiennummer: ClinicalTrials.gov Identifier: NCT04407949

Studientitel: Comparison of Sleep Disordered Breathing Events Detected by the CPAP Device „prismaLine“ with Polysomnography

Studieninhalt: Evaluation of residual sleep disordered breathing (SDB) under continuous positive airway pressure (CPAP) therapy with comparison of the automatic detected SDB event indices from CPAP machines with manual scored polysomnography (PSG).

Verantwortlicher Arzt: Prof Dr Georg Nilius

Status: Rekrutierung beendet

 

Rekonvaleszenten-Plasma mildert COVID-19-Verlauf bei Älteren.

Nilius G.

Pneumo Nachrichten. 2021; 13 (2): 14-16. doi: 10.1007 / s15033-021-2684-1. Epub 2021 17. Mai.

PMID: 33968265 Kostenloser PMC-Artikel. Deutsche. Keine Zusammenfassung verfügbar.

 

Effects of endobronchial coils for endoscopic lung volume reduction on sleep in COPD patients with advanced pulmonary emphysema.

Franke KJ, Domanski U, Schröder M, Nilius G.

Sleep Breath. 2020 Aug 26. doi: 10.1007/s11325-020-02176-0. Online ahead of print.

PMID: 32845475

 

Effects of continuous positive airway pressure therapy on daytime and nighttime arterial blood pressure in patients with severe obstructive sleep apnea and endothelial dysfunction.

Bischof F, Egresits J, Schulz R, Randerath WJ, Galetke W, Budweiser S, Nilius G, Arzt M, Hetzenecker A; GERSAN Investigators.

Sleep Breath. 2020 Sep;24(3):941-951. doi: 10.1007/s11325-019-01926-z. Epub 2019 Aug 28.

PMID: 31463779

 

Telemedicine Improves Continuous Positive Airway Pressure Adherence in Stroke Patients with Obstructive Sleep Apnea in a Randomized Trial.

Nilius G, Schroeder M, Domanski U, Tietze A, Schäfer T, Franke KJ.

Respiration. 2019 Aug 7:1-11. doi: 10.1159/000501656. Epub ahead of print PMID: 31390641

 

German Translation and Linguistic Validation of the Multidimensional Dyspnea Profile (MDP)
Stump A, Schröder M, Domanski U, Franke KJ, Nilius G.

Pneumologie. 2019 Aug; 73(8):470-473. doi: 10.1055/a-0861-1516. Epub 2019 Jun 17. German.  PMID: 31207660

 

Digital Health in Respiratory Medicine – Current Status.

Dreher M, Jany B, Nilius G, Woehrle H, Koczulla R.

Dtsch Med Wochenschr. 2019 Apr; 144(7):457-462. doi: 10.1055/a-0740-8692. Epub 2019 Mar

  1. German.

PMID: 30925600

 

German Sleep Apnea Research Network (GERSAN). CPAP therapy improves erectile function in patients with severe obstructive sleep apnea.

Schulz R, Bischof F, Galetke W, Gall H, Heitmann J, Hetzenecker A, Laudenburg M, Magnus TJ,

Nilius G, Priegnitz C, Randerath W, Schröder M, Treml M, Arzt M

Sleep Med. 2018 Apr 10. pii: S1389-9457(18)30096-0. doi: 10.1016/j.sleep.2018.03.018. Epub ahead of print] PubMed PMID: 29773460.

 

Humidity during CPAP: influence of ambient temperature, heated humidification and heated tubing.

Nilius G, Domanski U, Schroeder M, Woehrle H, Graml A, Franke KJ. Mask

Nat Sci Sleep. 2018 May 1;10:135-142. doi: 10.2147/NSS.S158856. eCollection 2018. PubMed PMID: 29750062; PubMed Central PMCID: PMC5935083.

 

COMET: a multicomponent home-based disease-management programme versus routine care in severe COPD.

Kessler R, Casan-Clara P, Koehler D, Tognella S, Viejo JL, Dal Negro RW, Díaz-Lobato S, Reissig K,

Rodríguez González-Moro JM, Devouassoux G, Chavaillon JM, Botrus P, Arnal JM, Ancochea J, Bergeron-Lafaurie A, De Abajo C, Randerath WJ, Bastian A, Cornelissen CG, Nilius G, Texereau JB, Bourbeau J.

Eur Respir J. 2018 Jan 11;51(1). pii: 1701612. doi: 10.1183/13993003.01612-2017. Print 2018 Jan. PubMed PMID: 29326333.

 

A randomized controlled trial to validate the Alice PDX ambulatory device.

Nilius G, Domanski U, Schroeder M, Franke KJ, Hogrebe A, Margarit L, Stoica M, d’Ortho MP.

Nat Sci Sleep. 2017 Jun 6;9:171-180. doi: 10.2147/NSS.S133789. eCollection 2017. PubMed PMID: 28652835; PubMed Central PMCID: PMC5476768.

 

Non-invasive ventilation with intelligent volume-assured pressure support versus pressurecontrolled ventilation: effects on the respiratory event rate and sleep quality in COPD with chronic hypercapnia.

Nilius G, Katamadze N, Domanski U, Schroeder M, Franke KJ.

Int J Chron Obstruct Pulmon Dis. 2017 Mar 30;12:1039-1045. doi: 10.2147/COPD.S126970.

eCollection 2017. PubMed PMID: 28408814; PubMed Central PMCID: PMC5383083.

 

Positionpaper on Telemonitoring in Sleep-Related Breathing Disorders.

Randerath W, Bögel M, Franke C, Hellmann A, Jany B, Nilius G, Penzel T, Voshaar T, Wiater A.

Pneumologie. 2017 Feb;71(2):81-85. doi: 10.1055/s-0042-124083. Epub 2017 Feb 21. German. PubMed PMID: 28222476.

 

Telemonitoring of home exercise cycle training in patients with COPD.

Franke KJ, Domanski U, Schroeder M, Jansen V, Artmann F, Weber U, Ettler R, Nilius G.

Int J Chron Obstruct Pulmon Dis. 2016 Nov 11; 11:2821-2829. eCollection 2016. PubMed PMID: 27956829; PubMed Central PMCID: PMC5113934.

 

Nasal high flow reduces dead space.

Möller W, Feng S, Domanski U, Franke KJ, Celik G, Bartenstein P, Becker S, Meyer G, Schmid O, Eickelberg O, Tatkov S, Nilius G.

J Appl Physiol (1985). 2017 Jan 1;122(1):191-197. doi: 10.1152/japplphysiol.00584.2016. Epub 2016 Nov 17. PubMed PMID: 27856714; PubMed Central PMCID: PMC5283847.

 

Nasal high flow reduces hypercapnia by clearance of anatomical dead space in a COPD patient.

Fricke K, Tatkov S, Domanski U, Franke KJ, Nilius G, Schneider H.

Respir Med Case Rep. 2016 Aug 26;19:115-7. doi: 10.1016/j.rmcr.2016.08.010.

eCollection 2016. PubMed PMID: 27668173; PubMed Central PMCID: PMC5024502.

 

A New Tool for Transbronchial Cryobiopsies in the Lung: An Experimental Feasibility ex vivo Study.

Franke KJ, Linzenbold W, Nuessle D, Enderle M, Boesmueller H, Nilius G, Hetzel J.

Respiration. 2016;91(3):228-34. doi: 10.1159/000443990. Epub 2016 Feb 23. PubMed PMID: 26901791.

 

Nasal Highflow (NHF): A New Therapeutic Option for the Treatment of Respiratory Failure.

Bräunlich J, Nilius G.

Pneumologie. 2016 Jan;70(1):49-54. doi: 10.1055/s-0041-110286. Epub 2016 Jan 20. Review. German. PubMed PMID: 26789432.

 

Response to „Effect of APAP and heated humidification with a heated breathing tube on adherence, quality of life, and nasopharyngeal complaints“.

Nilius G.

Sleep Breath. 2016 Mar;20(1):253. doi: 10.1007/s11325-015-1273-0. Epub 2015 Oct 17. PubMed PMID: 26476548.

 

Transbronchial Catheter Aspiration and Transbronchial Needle Aspiration in the Diagnostic Workup of Peripheral Lung Lesions.

Franke KJ, Hein M, Domanski U, Nilius G, Schroeder M, Wohlschlaeger J, Theegarten D.

Lung. 2015 Oct;193(5):767-72. doi: 10.1007/s00408-015-9763-1. Epub 2015 Jul 9. PubMed PMID: 26156311.

 

Effect of APAP and heated humidification with a heated breathing tube on adherence, quality of life and nasopharyngeal complaints.

Nilius G, Franke KJ, Domanski U, Schroeder M, Ruhle KH.

Sleep Breath. 2016 Mar;20(1):43-9. doi: 10.1007/s11325-015-1182-2. Epub 2015 May 10. PubMed PMID: 25957615.

 

When patients bring their own medical devices into hospital – position paper of the German Society for Sleep Research and Sleep Medicine, Section 8 of the German Society of Pneumology and the Association of Pneumological hospitals.

Kamps N, Galetke W, Hein H, Nilius G, Rühle KH, Voshaar T, Wiater A, Randerath W.

Dtsch Med Wochenschr. 2015 Feb;140(4):281-4. doi: 10.1055/s-0041-100479. Epub 2015 Feb 19. German. PubMed PMID: 25704526.

 

Randomized double blind placebo-controlled study to demonstrate that antibiotics are not needed in moderate acute exacerbations of COPD – the ABACOPD study.

Rohde GG, Koch A, Welte T; ABACOPD study group.

BMC Pulm Med. 2015 Jan 27;15:5. doi: 10.1186/1471-2466-15-5. PubMed PMID: 25623589; PubMed Central PMCID: PMC4350292.

 

Transnasal insufflation or continuous positive airway pressure (CPAP) in acute stroke. The next step or a new dilemma?

Esquinas AM, Nilius G.

Sleep Breath. 2015 Mar;19(1):1-2. doi: 10.1007/s11325-014-1061-2. Epub 2014 Oct 7. PubMed PMID: 25287008.

 

Consensus paper on the diagnosis and treatment of sleep disordered breathing.

Randerath WJ, Hein H, Arzt M, Galetke W, Nilius G, Penzel T, Rasche K, Rühle KH, Mayer G.

Pneumologie. 2014 Feb;68(2):106-23. doi: 10.1055/s-0033-1359221. Epub 2014 Feb 4. German. PubMed PMID: 24497048.

 

Unilateral reduction of lung volume by application of intrabronchial valves on patients selected after endoscopic collateral ventilation assessment.

Franke KJ, Nilius G, Domanski U, Rühle KH.

Pneumologie. 2014 Feb;68(2):100-5. doi: 10.1055/s-0033-1359025. Epub 2013 Dec 16. German. PubMed PMID: 24343242.

 

New developments in X-PAP therapy for obstructive and central sleep-disordered breathing.

Rühle KH, Franke KJ, Domanski U, Schröder M, Nilius G.

Pneumologie. 2013 Oct;67(10):551-9; quiz 560-1. doi: 10.1055/s-0033-1344494. Epub 2013 Oct 10. German. PubMed PMID: 24113886.

 

The cryo-needle: a new tool for histological biopsies. A feasibility study.

Franke KJ, Nilius G, Ruehle KH, Enderle MD, Linzenbold W, von Weyhern CH.

Lung. 2013 Dec;191(6):611-7. doi: 10.1007/s00408-013-9502-4. Epub 2013 Aug 30. PubMed PMID: 23990134.

 

Telemonitoring of bike exercise training in patients with obstructive sleep apnoea]. Pneumologie.

Rühle KH, Franke KJ, Domanski U, Schröder M, Nilius G.

2013 Jun;67(6):321-6. doi: 10.1055/s-0033-1344151. Epub 2013 May 22. German. PubMed PMID:

23700134.

 

Technique and clinical importance of breathing wave generators.

Rühle KH, Karweina D, Domanski U, Nilius G.

Pneumologie. 2012 Oct;66(10):579-83. doi: 10.1055/s-0032-1325665. Epub 2012 Sep 17. Review. German. PubMed PMID: 22987327.

 

Effects of nasal insufflation on arterial gas exchange and breathing pattern in patients with chronic obstructive pulmonary disease and hypercapnic respiratory failure.

Nilius G, Franke KJ, Domanski U, Rühle KH, Kirkness JP, Schneider H. Adv Exp Med Biol. 2013;755:27-34. PubMed PMID: 22826046.

 

Diagnosis and therapy of COPD exacerbation.

Bauer TT, Nilius G, Grüning W, Rasche K.

Med Klin Intensivmed Notfmed. 2012 Apr;107(3):172-8. doi: 10.1007/s00063-011-0065-y. Epub 2012 Apr 4. Review. German. PubMed PMID: 22476704.

 

Obstructive pressure peak: a new method for differentiation of obstructive and central apneas under auto-CPAP therapy.
Sleep Ruhle KH, Domanski U, Nilius G.
Breath. 2013 Mar;17(1):111-5. PubMed PMID: 22302201.

 

Detection of daytime sleepiness using Epworth Sleepiness Scale and a 3-item questionnaire in obstructive sleep apnea.

Rühle KH, Kuhtin O, Domanski U, Franke KJ, Nilius G.

Pneumologie. 2012 Mar;66(3):184-7. doi: 10.1055/s-0031-1291634. Epub 2012 Jan 27. German. PubMed PMID: 22287055.

 

The contribution of endobronchial ultrasound-guided forceps biopsy in the diagnostic workup of unexplained mediastinal and hilar lymphadenopathy.

Franke KJ, Bruckner C, Szyrach M, Ruhle KH, Nilius G, Theegarten D.

Lung. 2012 Apr;190(2):227-32. doi: 10.1007/s00408-011-9341-0. Epub 2011 Oct 22. PubMed PMID: 22037795.

 

Investigation of the flexibility of bronchoscopes.

Franke KJ, Bruckner C, Nilius G, Ruhle KH.

Eur J Med Res. 2011 Sep 12;16(9):420-4. PubMed PMID: 22024444; PubMed Central PMCID: PMC3352149.

 

Telemedicine and training in COPD]. Pneumologie.

Rühle KH, Domanski U, Franke KJ, Bloch M, Nilius G.

2011 Oct;65(10):596-601. doi:  10.1055/s-0030-1256738. Epub 2011 Oct 20. Review. German. PubMed PMID: 22015486.

 

Clinical views on biosignal processing of ventilation in sleep medicine.

Rühle KH, Karweina D, Domanski U, Nilius G.

Pneumologie. 2011 Feb;65(2):89-93. doi: 10.1055/s-0030-1255819. Epub 2010 Oct 18. Review. German. PubMed PMID: 20957599.

 

Quality of life, compliance, sleep and nasopharyngeal side effects during CPAP therapy with and without controlled heated humidification.

Ruhle KH, Franke KJ, Domanski U, Nilius G.

Sleep Breath. 2011 Sep;15(3):479-85. doi: 10.1007/s11325-010-0363-2. Epub 2010 May 26. PubMed PMID: 20503074.

 

Removal of the tracheal tube after prolonged mechanical ventilation: assessment of risk by oscillatory impedance.

Franke KJ, Nilius G, Morgenstern S, Ruhle KH.

Respiration. 2011;81(2):118-23. doi: 10.1159/000314073. Epub 2010 Apr 27.

PubMed PMID:  20424425.

 

Use of cryoextraction in different types of airway obstruction.

Franke KJ, Nilius G, Rühle KH.

Pneumologie. 2010 Jun;64(6):387-9. doi: 10.1055/s-0029-1244046. Epub 2010 Apr 13. German. PubMed PMID: 20391320.

 

Heated humidification during CPAP with and without tube insulation.

Rühle KH, Domanski U, Schröder M, Franke KJ, Nilius G.

Pneumologie. 2010 May;64(5):316-9. doi: 10.1055/s-0029-1244073. Epub 2010 Apr 12. German. PubMed PMID: 20387197.

 

Prospective controlled animal study on biopsy sampling with new flexible cryoprobes versus forceps: evaluation of biopsy size, histological quality and bleeding risk.

Franke KJ, Theegarten D, Hann von Weyhern C, Nilius G, Brueckner C, Hetzel J, Hetzel M, Ruhle KH, Enderle MD, Szyrach MN. Respiration. 2010;80(2):127-32. doi: 10.1159/000287251. Epub 2010 Feb 17. PubMed PMID: 20160432.

 

Predictors for treating obstructive sleep apnea with an open nasal cannula system (transnasal insufflation).

Nilius G, Wessendorf T, Maurer J, Stoohs R, Patil SP, Schubert N, Schneider H.

Chest. 2010 Mar;137(3):521-8. doi: 10.1378/chest.09-0357. Epub 2009 Dec 1. PubMed PMID: 19952061.

 

Effects of a breath-triggered modulation of positive airway pressure ventilation on the AHI from patients with obstructive sleep apnoea.

Nilius G, Burian S, Franke KJ, Van’t Hoog T, Domanski U, Rühle KH.

Pneumologie. 2009 Aug;63(8):433-8. doi: 10.1055/s-0029-1214817. Epub 2009 Aug 7. German. PubMed PMID: 19670102.

 

Characteristics of auto-CPAP devices during the simulation of sleep-related breathing flow patterns.

Rühle KH, Karweina D, Domanski U, Nilius G.

Pneumologie. 2009 Jul;63(7):390-8. doi: 10.1055/s-0029-1214746. Epub 2009 Jul 9. German. PubMed PMID: 19591085.

 

Experimental study on biopsy sampling using new flexible cryoprobes: influence of activation time, probe size, tissue consistency, and contact pressure of the probe on the size of the biopsy specimen.

Franke KJ, Szyrach M, Nilius G, Hetzel J, Hetzel M, Ruehle KH, Enderle MD.

Lung. 2009 Aug;187(4):253-9. doi: 10.1007/s00408-009-9156-4. Epub 2009 Jun 23. PubMed PMID: 19548030.

 

Telemonitoring of arm ergometric training in COPD patients. A pilot study.

Rühle KH, Bloch M, Franke KJ, Nilius G.

Pneumologie. 2009 Jun;63(6):314-8. doi: 10.1055/s-0028-1119701. Epub 2009 Mar 16. German. PubMed PMID: 19291617.

 

Transbronchial catheter aspiration compared to forceps biopsy in the diagnosis of peripheral lung cancer.

Franke KJ, Nilius G, Ruhle KH.

Eur J Med Res. 2009 Jan 28;14(1):13-7. PubMed PMID: 19258205; PubMed Central PMCID: PMC3352199.

 

Treatment of malignant pleural effusion with the trifunctional antibody catumaxomab (Removab) (anti-EpCAM x Anti-CD3): results of a phase 1/2 study.

Sebastian M, Kiewe P, Schuette W, Brust D, Peschel C, Schneller F, Rühle KH, Nilius G, Ewert R,

Lodziewski S, Passlick B, Sienel W, Wiewrodt R, Jäger M, Lindhofer H, Friccius-Quecke H, Schmittel J Immunother. 2009 Feb-Mar;32(2):195-202. doi: 10.1097/CJI.0b013e318195b5bb. PubMed PMID: 19238019.

 

Exercise testing by spiroergometry in a patient with sarcoidosis stage II. An unusual combination of functional impairments.

Rühle KH, Franke KJ, Morgenstern S, Nilius G.

Pneumologie. 2009 Feb;63(2):80-5. doi: 10.1055/s-0028-1119434. Epub 2009 Feb 13. German. PubMed PMID: 19219768.

 

Microsleep, sleepiness and driving performance in patients with sleep apnoea syndrome.

Rühle KH, Franke KJ, Nilius G.

Pneumologie. 2008 Oct;62(10):595-601. doi: 10.1055/s-2008-1038203. Epub 2008 Aug 18. Review. German. PubMed PMID: 18711696.

 

Impact of a controlled heated breathing tube humidifier on sleep quality during CPAP therapy in a cool sleeping environment.

Nilius G, Domanski U, Franke KJ, Ruhle KH.

Eur Respir J. 2008 Apr;31(4):830-6. doi: 10.1183/09031936.00161806. Epub 2008 Jan 9. PubMed PMID: 18184678.

 

Mouth breathing in obstructive sleep apnea prior to and during nasal continuous positive airway pressure.

Ruhle KH, Nilius G.

Respiration. 2008;76(1):40-5. Epub 2007 Nov 28. PubMed PMID: 18042974.

 

Studies of leakage measurements of automatic CPAP-devices.

Rühle KH, Domanski U, Franke KJ, Nilius G.

Pneumologie. 2007 Apr;61(4):213-8. German. PubMed PMID: 17455133.

 

Analysis of expiratory pressure reduction (C-Flex method) during CPAP therapy.

Rühle KH, Domanski U, Happel A, Nilius G.

Pneumologie. 2007 Feb;61(2):86-9. German. PubMed PMID: 17290312.

 

Upper airway complaints of patients with obstructive sleep apnea – effect of CPAP
Nilius G, Franke KJ, Domanski U, Rühle KH.

Pneumologie. 2007 Jan;61(1):15-9. German. PubMed PMID: 17253207.

 

Frequency of cytological procedures in diagnostic bronchoscopy of peripheral pulmonary modules and masses.

Franke KJ, Nilius G, Rühle KH.

Pneumologie. 2006 Nov;60(11):663-6. German. PubMed PMID: 17109263.

 

Pressure-relief continuous positive airway pressure vs constant continuous positive airway pressure: a comparison of efficacy and compliance.

Nilius G, Happel A, Domanski U, Ruhle KH.

Chest. 2006 Oct;130(4):1018-24. PubMed PMID: 17035433.

 

Transbronchial biopsy in comparison with catheter aspiration in the diagnosis of peripheral pulmonary nodules.

Franke KJ, Nilius G, Rühle KH.

Pneumologie. 2006 Jan;60(1):7-10. German. PubMed PMID: 16429388.

 

Cryorecanalization of an endobronchial lipoma.

Franke KJ, Nilius G, Rühle KH.

Pneumologie. 2005 Oct;59(10):685-8. German. PubMed PMID: 16222580